Doses of sodium bicarbonate at 5%, as indicated in the Simoncini treatment are innocuous. In fact they have been used without any problems for over 30 years in a multitude of other deseases such as:
- Severe diabetic ketoacidosis (1)
- Cardiopulmonary resuscitation (2)
- Pregnancy (3)
- Hemodialysis (4)
- Peritoneal dialysis. (5)
- Pharmacological toxicosis. (6)
- Hepatopathy. (7)
- Vascular surgery operations (8)
1. Gamba, G., “Bicarbonate therapy in severe diabetic ketoacidosis. A double blind, randomized, placebo controlled trial.” (Rev Invest Clin 1991 Jul-Sep;43(3):234-8). Miyares Gomez A. in “Diabetic ketoacidosis in childhood: the first day of treatment (An Esp Pediatr 1989 Apr;30(4):279-83).
2. Levy, M.M., “An evidence-based evaluation of the use of sodium bicarbonate during cardiopulmonary resuscitation” (Crit Care Clin 1998 Jul;14(3):457-83). Vukmir, R.B., Sodium bicarbonate in cardiac arrest: a reappraisal (Am J Emerg Med 1996 Mar;14(2):192-206). Bar-Joseph, G., “Clinical use of sodium bicarbonate during cardiopulmonary resuscitation--is it used sensibly?” (Resuscitation 2002 Jul;54(1):47-55).
3. Zhang. L.,“Perhydrit and sodium bicarbonate improve maternal gases and acid-base status during the second stage of labor” Department of Obstetrics and Gynecology, Xiangya Hospital, Hunan Medical University, Changsha 410008. Maeda, Y., “Perioperative administration of bicarbonated solution to a patient with mitochondrial encephalomyopathy” (Masui 2001 Mar;50(3):299-303).
4. Avdic. E., “Bicarbonate versus acetate hemodialysis: effects on the acid-base status” (Med Arh 2001;55(4):231-3).
5. Feriani, M., “Randomized long-term evaluation of bicarbonate-buffered CAPD solution.” (Kidney Int 1998 Nov;54(5):1731-8).
6. Vrijlandt, P.J., “Sodium bicarbonate infusion for intoxication with tricyclic antidepressives: recommended inspite of lack of scientific evidence” Ned Tijdschr Geneeskd 2001 Sep 1;145(35):1686-9). Knudsen, K., “Epinephrine and sodium bicarbonate independently and additively increase survival in experimental amitriptyline poisoning.” (Crit Care Med 1997 Apr;25(4):669-74).
7. Silomon, M., “Effect of sodium bicarbonate infusion on hepatocyte Ca2+ overload during resuscitation from hemorrhagic shock.” (Resuscitation 1998 Apr;37(1):27-32). Mariano, F., “Insufficient correction of blood bicarbonate levels in biguanide lactic acidosis treated with CVVH and bicarbonate replacement fluids” (Minerva Urol Nefrol 1997 Sep;49(3):133-6).
8. Dement'eva, I.I., “Calculation of the dose of sodium bicarbonate in the treatment of metabolic acidosis in surgery with and deep hypothermic circulatory arrest” (Anesteziol Reanimatol 1997 Sep-Oct;(5):42-4).
more chemical information about sodium bicarbonate (pdf)
