the noisy researches on cancer

Oncological studies represent the emplematic example of a particular verbal instrument, tall story telling, which is capable of hiding with its infinite yet refined inconclusiveness, a state of complete ignorance and failure. Tall story telling is such when it starts from undemonstrated theories or suppositions, goes through a long series of demonstrations and logical connections and gradually projects a light of truthfulness stronger and stronger from the first to the last sentence, up to the evidence of a truth which remains however only at a supposition level, since its constituting elements remain in a dimension of mystery.

The most risky consequence of such a way of presenting things is that whoever reads or studies the apparently “true” conclusions onsiders them true, accepting de facto all the cock and bull stories they have deceitfully been dished up.

The outline proceeding can be described as follows:

Unknown fact → first supposition → enucleation of one or more supporting elements → demonstration of their existence and validity → convincing and well demonstrable deductions → supposition of a high connection between the demonstrated data and the first explanatory supposition → suggestive or illusory effect that the fact they wish to explain corresponds to the proposed theory.

A student or a scholar who is not watchful or who lacks any sound judgement ends up with accepting totally untrue conclusions, with the aggravating circumstance that he might take those as valid or as starting points for other studies and researches, thus contributing to thicken the mystery.

Analysing into details the studies and researches on tumours, it comes spontaneous to make a preliminary consideration: if upon regular deadlines, almost every month, this or that fundamental discovery is published, which is capable of solving or improving the knowledge of neoplasies, one should suspect that these researches are all cock and bull stories, that is useless and false.

Looking into the merits of these studies, often highlighted and trumpeted everywhere, one realizes that they are utter nonsense, suspended in a vacuum, without logical starting assumptions and solid perspectives.

 

March 2004
An anomalous structure of the lymphocytes’ Dna chromosome seems to predispose to the development of follicular lymphoma. The discovery has been made by the team of Michael R. Lieber of the American University of Southern California

March 2004
Some scientists have discovered a new surprising target for anti-cancer drugs: the IGF-1R receptor.

March 2004
Staminal cells tested on mice, were able to kill various kinds of neoplasies. Michael Andreeff of the Texas Anderson Cancer Center University in Houston, announced at the meeting of the American Association of Cancer Research in progress in Orlando, Florida.

April 2004
Soya beans may help prevent prostate cancer, at least according to a study lead by some US research of the Colorado State’s College of Veterinary Medicine and published on the magazine Biology of Reproduction.

April 2004
A computer entirely composed of biological molecules able to work inside the human body and look for cancer in the making. It was made by Ehud Shapiro of Weizmann Institute of Science of Rehovot, Israel, who presented his work in the magazine Nature.

May 2004
Cycloxigenase (Cox) has a key role in breast carcinogenesis.
* Bull Cancer. 2004 May;91 Spec No:S99-108

May 2004
Gefitinib disactivates a protein which favours cellular growth. This was discovered by the researchers of Dana Farber Institute and of Massachussets General Hospital Cancer Center in Boston

July 2004
Effectiveness and safety of trastuzumab
Expert Opin Drug Saf. 2004 Jul;3(4):317-27.

August 2004
Hsp 90: a new target in breast cancer therapy.
Anticancer Drugs. 2004 Aug;15(7):651-662.

September 2004
Identified cell responsible for stomac cancer

October 2004
TGF-beta may suppress the development of colon rectum cancer.
The study was made in Germany at the Mainz University.

October 2004
A team of researchers has discovered a genetic mutation which provokes an aggressive form of children’s leukaemia. Andrew Weng and his colleagues of the Brigham and Women’s Hospital of Harvard Medical School in Boston have found out that in almost 60% of all T-ALL cancers there are mutation of a gene called NOTCH1

October 2004
Identified the disordered staminal cells which cause the most dangerous of brain cancers. The study, published on Cancer Research has been conducted by the research institute of staminal cells of the San Raffaele hospital.

January 2005
Chemotherapy resistance may depend on the transfer of a protein. The study, published online on the magazine “Proceedings of the National Academy of Sciences” by researchers of the Memorial Sloan-Kettering Cancer Center of New York and of the Johns Hopkins University of Baltimora provides new hints on how cancer cells may become resistant to anti cancer therapies.

January 2005
Leukaemia. And cells suicide
They are called deacetylasei inhibitors and they are substances able to reactivate the apoptosis, the safety procedure which induces the cells which have accumulated gene mutations to suicide. The study has been published in Nature Medicine.

January 2005
In a study providing new information on the cause of some types of skin cancer caused by UV rays, the researchers of the Erasmus University Medical Center of Rotterdam have used an old enzyme, photolysis, which placental mammals are no longer able to produce, in order to identify the main damage responsible for skin cancer development. The results have been published in the magazine “Current Biology”.

January 2005
Pokemon gene
It is the main responsible for the formation, development and growth of cancer cells. The discovery, published today in Nature is owed to a Roman researcher, who has been working for years in the US, where he is the director of the Cancer Biology and Genetics Laboratory, at the Memorial Sloan Kettering Cancer Center of New York.

January 2005
Sugar and cancer risk.
Also diabetes may increase cancer possibilities.
According to the researchers of the John Hopkins Bloomberg School of Public Health and the Yonsei University in Seul, South Corea, high levels of glucose in the blood and diabetes are risk factors for the development of various types of cancer. The study has been published in the issue dated 12 January 2005 of the magazine “Journal of the American Medical Association”.

February 2005
The researchers now need to develop second generation drugs. In an article published in the magazine “PLoS Medicine”, William Pao and his colleagues of the Memorial Sloan-Kettering Cancer Center of New York investigate on the causes of the resistance to two recently approved drugs against lung cancer.

The medicines at hand are the so called kinase inhibitors, in particular of protein EGFR (skin growth factor receptor). Both medicines, gefitinib (Iressa) and erlotinib (Tarceva), provide therapeutic benefits to a specific sub group of lung cancer patients

March 2005
The researchers may develop new drugs based on the EGCG molecule structure.
A group of scientists of the University of Murcia, in Spain, in collaboration with the John Innes Centre (JIC) of Norwich, UK, have found out that a poliphenole isolated from green tea leaves, or EGCG) inhibits the growth of cancer cells. The research, financed by the EU has been published in the magazine “Cancer Research”

March 2005
The researchers now need to develop second generation drugs. In an article published in the magazine “PLoS Medicine”, William Pao and colleagues of the Memorial Sloan-Kettering Cancer Center of New York investigate on the causes of the resistance to two recently approved drugs against lung cancer.

The medicines at hand are the so called kinase inhibitors, in particular of protein EGFR (skin growth factor receptor). Both medicines, gefitinib (Iressa) and erlotinib (Tarceva), provide therapeutic benefits to a specific sub group of lung cancer patients

March 2005
The forerunner of melanoma.
A protein has been discovered which is responsible for the spreading of cancer cells in skin cancer. This is stated by a group of researchers of the School of Medicin of Stanford University, in an article published in Science.

March 2005
Some types of cancer spread also in the absece of PTEN mutations. Some scientists have discovered that a molecule called DJ-1 is probably involved in the generation of human cancer by means of the negative regulation of a well known cancer suppressor, PTEN. The research, published in the March issue of the magazine “Cancer Cell”, presents majour implications for determining the prognosis of some types of human cancer and may provide a good target for therapies.

April 2005
Antioxidants increase cancer risk.
The result has been puzzling, since the authors thought that integrating vitamin E might reduce or delay the risk of a second primary cancer. (J Natl Cancer Inst 2005; 97: 481-8)

May 2005
New test for ovarian cancer
A new blood test consents to diagnose ovarian cancer, announce a group of researchers of the School of Medicine of Yale University on the last issue of the magazine Proceedings of the National Academies of Sciences (Pnas).

July 2005
Promising results for a new medicine against lung cancer.
Promising results for a new anti cancer drug, erlotinib, against lung cancer. The study has been published in the ‘New England Journal of Medicine’.  The medicine belongs to a new class of anti cancer drugs, the EGFR inhibitors (inhibitors of the sking growth factor receptor). The research, published in the NEJM has been conducted by the National Cancer Institute of Canada. N. Engl J Med:2005 Jul 14;353(2):133-44

August 2005
A new DNA detail discovered in the development of tumours .
A new DNA detail has been discovered in the development of thyroid cancers. A study by the Institute of neurobiology and molecular medicine of the National Research Council, just published in the scientific magazine ‘Oncogene’, ascribes a new role to protein retinoblastoma  in the molecular mechanisms which lead to the neoplastic transformation of thyroid cells. Oncogene 2005 Jun 27

August 2005
The genic expression may mark in advance the spreading of metastases. Researchers have a job in understanding why cancer cells migrate towards one organ rather than another. A new study, published on 28 July in the magazine “Nature”, may however provide an important indication, showing that cancer cells contain a particular genic signature indicating if – and where – they will move to. Biologist Joan Massagué of Memorial Sloan-Kettering Cancer Center of New York made this discovery studying metastases of breast cancer.

August 2005
Nanocells against cancer.
Nanoparticles are used as “Troian horses”. Some researchers of Massachusetts Institute of Technology have developed a nanocell able to penetrate a tumour, cut its blood supplies and detonate a letal dose of anti-cancer toxins. The double action therapy, whose effectiveness has been experimented against melanoma and a form of lung cancer in mice, leaves the sound cells whole.
*The details have been published in the magazine “Nature”

September 2005
Intelligent bomb against cancer.
The first anti-cancer intelligent bomb has been designed. This has been stated by a group of researchers of the Massachussets Institute of Technology in the last issue of Nature. The engineers of the Biological Engineering Division of Mit have produced a nanoparticle capable of penetrating the cancer cell, blocking the exits and exploding discharging a dose of anti-cancer toxins. Result: killing of the cancer cell without endangering the other healthy cells

September 2005
Discovered the cells which “feed” tumours .
The researchers of the Istituto Universitario Scientifico San Raffaele of Milan have found out that the formation of blood vases of various types of cancer needs a rare population of blood cells, the TEM.
*This research, published in Cancer Cell, has elaborated an effective system of genic transfer based on an inactivated version of the Hiv virus.

September 2005
There is a connection between the tissues’ tension and cancer formation. Most studies on cancer focus on chemical marks but now a new research provides interesting indications on how mechanic forces may regulate the cellular behavious. The study is published in the September issue of “Cancer Cell”, Matthew J. Paszek, et al., “Tensional homeostasis and the malignant phenotype”.
* Cancer Cell. Vol 8, pp. 241-254 DOI 10.1016/j.ccr.2005.08.010 (SEPTEMBER 2005)

September 2005
Stress prevents cancer.
This discovery contradicts the results of previous studies. According to a study by some Danish researchers published in the magazine “British Medical Journal” and based on the answers to a questionnaire by approximately 7000 women who have lived in Copenhagen between 1981 and 1983, high daily stress levels may lower the risk of breast cancer. This discovery contradicts the results of previous researches, according to which stress doubled the risk.

September 2005
Peanuts against cancer.
Many legumes and various types of nuts contain an anti-cancer substance. It is the inosytol pentaphosphate, a molecule able to oppose the activation of a key mechanism for the survival of cancer cells. It was identified by the researchers of the Medicine Department of the University College of Londra, together with the Surgery department of the Chieti Univeristy and the laboratory of Molecular Pharmacology of Istituto Mario Negri of Milano. This study has been published in Cancer Research.

Considerations:

There is little to say.
Super qualified scientists, super thorough researches, super prestigious research institutes, super credited scientific magazines: all this to produce super nonsense.
Usque tandem? Until when shall we suffer to be so blatantly deceived?
Enough with sitting room chats. Cancer is something serious.


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