We have to hypothesise that Candida, in the moment it is attacked by the immunological system of the host or by a conventional antimycotic treatment, does not react in the usual, predicted way, but defends itself by transforming itself into ever-smaller and non-differentiated elements that maintain their fecundity intact to the point of hiding their presence both to the host organism and to possible diagnostic investigations.
The Candida’s behaviour may be considered to be almost elastic:
When favourable conditions exist, it thrives on an epithelium; as soon as the tissue reaction is engaged, it massively transforms itself into a form that is less productive but impervious to attack — the spore.
If then continuous sub-epithelial solutions take place coupled with a greater a-reactivity in that very moment the spore gets deeper in the lower connective tissue in such an impervious state, it is irreversible.
In fact, the Candida takes advantage of a structural interchangeability utilising, according to the difficulties to overcome its biological niche.
In this way, Candida is free to expand to maturation in the soil, air, water, vegetation, etc., that is, wherever there is no antibody reaction.
In the epithelium, instead, it takes a mixed form, that is reduced to the sole spore component when it penetrates in the lower epithelial levels, where it tends to expand again in the presence of conditions tissular a-reactivity.
The initial mandatory step of an in-depth research endeavour would be to understand if and in which dimensions the spore transcends; what mechanisms it engages to hide itself or, again, if it preserves its parasitical characteristic, or if it has available a neutral quiescent position, which is difficult or even impossible to detect by the immunological system.
Unfortunately today we do not have the appropriate means, either theoretical or technical, to answer these and similar questions, so that the only valid suggestions can come solely from clinical observation and experience. While not providing immediate solutions, these sources can at stimulate further questions.
Assuming that Candida Albicans is the agent responsible for tumoral development, a targeted therapy would keep into account not just its static and macroscopic manifestations, but even the ultramicroscopic ones especially in their dynamic valence, that is, the reproductive.
It is very probable that the targets to attack are the fungi’s dimensional transition points in order to perform a decontamination with such a scope as to include the whole spectrum of the biological expression: parasitic, vegetative, sporal, and even ultra-dimensional and, to the limit, viral.
If we stop at the most evident phenomena, we risk administering salves and unguents forever (in the case of dermatomycosis or in psoriasis), or to clumsily attack (with surgery, radiotherapy or chemotherapy) enigmatic tumoral masses with the sole result of facilitating their propagation, which is already heightened in the mycelial forms.
Why, one may ask, should we assume a different and heightened activity of Candida Albicans since it has been abundantly described in its pathological manifestations?
The answer lies in the fact that it has been studied only in a pathogenic context, that is, only in relation to the epithelial tissues. In reality Candida possesses an aggressive valence that is diversified in function of the target tissue. It is just in the connective or in the connective environment, in fact, and not in the differentiated tissues, that Candida may find conditions favourable to an unlimited expansion.
This emerges if we stop and reflect for a moment on the main function of connective tissue, which is to convey and supply nourishing substances to the cells of the whole organism.
This is to be considered as an environment external to the more differentiated cells such as nervous, muscular, etc. It is in this context, in fact, that the alimentary competition takes place.
On one hand we have the organism’s cellular elements trying to defeat all forms of invasion; on the other hand, we have fungal cells trying to absorb ever-growing quantities of nourishing substances, for they have to obey the species’ biological imperative to form ever-larger and diffused masses and colonies.